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Artículos Destacados

Pe rez-Cruz, E., Barrientos-Jime nez, M., Camacho-Guerra, C. D., Tapia-Go mez, Y., Torres-Gonza lez, K. O.,
y Uribe-Quiroz, G. (2017). Problemas nutricionales en pacientes con enfermedades neurolo gicas.
Revista del Hospital Juárez de México, 84(1), 26-36.

Disponible en: http://www.medigraphic.com/pdfs/juarez/ju-2017/ju171f.pdf

Resumen

Las enfermedades neurolo gicas, tanto agudas como cro nicas, se han convertido en uno de los principales problemas de
salud debido al incremento en el nu mero de accidentes, enfermedades cerebrovasculares y demencia, entre otras. La
terapia nutricional adecuada es esencial para la recuperacio n de los pacientes con enfermedades neurolo gicas. La
evaluacio n y los requerimientos nutricionales son diferentes para cada patologí a y dependen de las caracterí sticas clí nicas
y posibilidades del individuo. El artí culo presenta una revisio n de los aspectos nutricionales ma s relevantes.

Palabras clave: Enfermedades neurológicas, disfagia, desnutrición, deshidratación.

Huey, E. D., Lee, S., Cheran, G., Grafman, J., & Devanand, D. P. (2017). Brain Regions Involved in
Arousal and Reward Processing are Associated with Apathy in Alzheimer’s Disease and
Frontotemporal Dementia. Journal of Alzheimer´s Disease, 55(2), 551-558.

Disponible en: http://goo.gl/DcqozB

Resumen

BACKGROUND: Apathy is a common and problematic symptom of several neurodegenerative illnesses, but its
neuroanatomical bases are not understood.
OBJECTIVE: To determine the regions associated with apathy in subjects with mild Alzheimer’s disease (AD) using a
method that accounts for the significant co-linearity of regional atrophy and neuropsychiatric symptoms.
METHODS: We identified 57 subjects with mild AD (CDR = 1) and neuropsychiatric symptoms in the Alzheimer’s Disease
Neuroimaging Initiative (ADNI) database. We performed a multivariate multiple regression with LASSO regularization on
all symptom subscales of the Neuropsychiatric Inventory and the whole-brain ROI volumes calculated from their baseline
MRIs with FreeSurfer. We compared our results to those from a previous study using the same method in patients with
frontotemporal dementia (FTD) and corticobasal syndrome (CBS).
RESULTS: Of neuropsychiatric symptoms, apathy showed the most robust neuroanatomical associations in the AD
subjects. Atrophy of the following regions were independently associated with apathy: the ventromedial prefrontal
cortex; ventrolateral prefrontal cortex; posterior cingulate cortex and adjacent lateral cortex; and the bank of the superior
temporal sulcus. These results replicate previous studies using FTD and CBS patients, mostly agree with the previous
literature on apathy in AD, and correspond to the Medial and Orbital Prefrontal Cortex networks identified in non-human
primates.
CONCLUSION: The current study, previous studies from our laboratory, and the previous literature suggest that
impairment of the same brain networks involved in arousal, threat response, and reward processing are associated with
apathy in AD and FTD.

Palabras clave: Apathy, Alzheimer’s disease, Frontotemporal dementia, Magnetic resonance imaging.