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Artículos Destacados

Sa nchez Iglesias, A., del Barrio, J. A., Gonza lez-Santos, J., Castro, F. V., Gonza lez, J., Padilla, D., ... y Gonza lez
Barbadillo, A. (2017). Mindfulness y rehabilitacio n neurocognitiva. International Journal of Developmental and
Educational Psychology, 1(1), 21-34.
Disponible en: http://www.redalyc.org/pdf/3498/349852544003.pdf

Resumen
Los u ltimos datos aportados por la Comisio n Europea sen alan que la demencia afecta actualmente a casi cincuenta
millones de personas en todo el mundo y que cada an o se detectan 7.7 millones de nuevos casos. A dí a de hoy, el
Alzheimer es la demencia ma s padecida por la poblacio n mundial pudiendo constituir en te rminos relativos el 70% de las
demencias. En la actualidad no existen tratamientos farmacolo gicos que den una respuesta definitiva a este tipo de
patologí as. Las utilizaciones de terapias no farmacolo gicas abren un amplio abanico de posibilidades desde el a mbito de la
prevencio n, y de la mejora de la calidad de vida en cuidadores y familiares de enfermos con demencia, ba sicamente con
sintomatologí a de “sobrecarga”. En este articulo hacemos una revisio n sobre investigaciones relacionadas con la “atencio n
plena” ( MF) y de su implementacio n como estrategias potenciales en el abordaje de este tipo de patologí as. Los u ltimos
trabajos aportados con te cnicas morfome tricas por neuroimagen constituyen un importante avance a la hora de intentar
aportar evidencia cientí fica en este campo.

Palabras clave: Demencias, Mindfulness, Rehabilitación.

Haaksma, M. L., Vilela, L. R., Marengoni, A., Caldero n-Larran aga, A., Leoutsakos, J. M. S., Rikkert, M. G.
O., & Melis, R. J. (2017). Comorbidity and progression of late onset Alzheimer’s disease: A systematic
review. PloS one, 12(5),1-15

Disponible en: http://journals.plos.org/plosone/article/file?id=10.1371/
journal.pone.0177044&type=printable

Resumen
Background Alzheimer´s disease is a neurodegenerative syndrome characterized by multiple dimensions including
cognitive decline, decreased daily functioning and psychiatric symptoms. This systematic review aims to investigate the
relation between somatic comorbidity burden and progression in late-onset Alzheimer´s disease (LOAD). Methods We
searched four databases for observational studies that examined cross-sectional or longitudinal associations of cognitive
or functional or neuropsychiatric outcomes with comorbidity in individuals with LOAD. From the 7966 articles identified
originally, 11 studies were included in this review. The Newcastle-Ottawa quality assessment was used. The large
variation in progression measures, comorbidity indexes and study designs hampered the ability to perform a meta-
analysis. This review was registered with PROSPERO under DIO: 10.15124/CRD42015027046. Results Nine studies
indicated that comorbidity burden was associated with deterioration in at least one of the three dimensions of LOAD
examined. Seven out of ten studies investigating cognition found comorbidities to be related to decreased cognitive
performance. Five out of the seven studies investigating daily functioning showed an association between comorbidity
burden and decreased daily functioning. Neuropsychiatric symptoms (NPS) increased with increasing comorbidity
burden in two out of three studies investigating NPS. Associations were predominantly found in studies analyzing the
association cross-sectionally, in a time-varying manner or across short follow-up ( 2 years). Rarely baseline comorbidity
burden appeared to be associated with outcomes in studies analyzing progression over longer follow- up periods (>2
years). Conclusion This review provides evidence of an association between somatic comorbidities and multifaceted
LOAD progression. Given that time-varying comorbidity burden, but much less so baseline comorbidity burden, was
associated with the three dimensions prospectively, this relationship cannot be reduced to a simple cause-effect relation
and is more likely to be dynamic. Therefore, both future studies and clinical practice may benefit from regarding
comorbidity as a modifiable factor with a possibly fluctuating influence on LOAD.

Palabras clave: Enfermedad de Alzheimer, Comorbilidad.